Zebrafish Rohon-Beard Neuron Development: Cdk5 in the Midst
نویسندگان
چکیده
منابع مشابه
Activity regulates programmed cell death of zebrafish Rohon-Beard neurons.
Programmed cell death is a normal aspect of neuronal development. Typically, twice as many neurons are generated than survive. In extreme cases, all neurons within a population disappear during embryogenesis or by early stages of postnatal development. Examples of transient neuronal populations include Cajal-Retzius cells of the cerebral cortex and Rohon-Beard cells of the spinal cord. The nove...
متن کاملdlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula.
Rohon-Beard sensory neurons, neural crest cells, and sensory placodes can be distinguished at the boundary of the embryonic epidermis (skin) and the neural plate. The inductive signals at the neural plate border region are likely to involve a gradient of bone morphogenic protein (BMP) in conjunction with FGF and Wnts and other signals. However, how these signals are transduced to produce the fi...
متن کاملIdentification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
Electrically excitable cells have voltage-dependent ion channels on the plasma membrane that regulate membrane permeability to specific ions. Voltage-gated Ca(2+) channels (VGCCs) are especially important as Ca(2+) serves as both a charge carrier and second messenger. Zebrafish (Danio rerio) are an important model vertebrate for studies of neuronal excitability, circuits, and behavior. However,...
متن کاملRohon-Beard neuron origin from blastomeres of the 16-cell frog embryo.
Clonal origins of Rohon-Beard neurons in Xenopus were determined quantitatively by injecting horseradish peroxidase into individual blastomeres at the 16-cell stage and later counting labeled and unlabeled Rohon-Beard neurons. Two different patterns of cleavage were selected. In pattern X, all Rohon-Beard neurons originated from three blastomeres (V1.1, V1.2, and V2.2) on each side; in pattern ...
متن کاملProgrammed cell death in zebrafish rohon beard neurons is influenced by TrkC1/NT-3 signaling.
Rohon Beard (RB) cells are embryonic primary sensory neurons that are removed by programmed cell death during larval development in zebrafish. RB somatosensory functions are taken over by neurons of the dorsal root ganglia (DRG), suggesting that RB cell death may be triggered by the differentiation of these ganglia, as has been proposed to be the case in Xenopus. However, here we show that the ...
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ژورنال
عنوان ژورنال: Neurochemical Research
سال: 2008
ISSN: 0364-3190,1573-6903
DOI: 10.1007/s11064-008-9885-4